Overview
Kensey Nash’s Porous Tissue MatrixTM (PTM) technology creates devices
with highly interconnected porosity from a variety of resorbable and non-resorbable
polymers. Using proprietary processing methods, many different architectures can be
produced to meet specific performance characteristics of end-use products.
PTM materials have been formed into cylinders, cubes, granules, spheres, micro spheres, hollow tubes, and sheets. PMA approval, 510(k) clearance and CE Mark have been received for PTM-based products.

Capabilities
With our PTM process, we have many alternatives to produce a custom matrix for your medical device needs including:

• Size of Pores: Average pore size can vary from less than 10 μm to greater than
200 μm • Fillers: ceramics, colorants, fibers, and drugs can be added
• Surface Properties: the material can be made either hydrophobic, hydrophilic, or
have multiple properties within the same device
• Density: scaffolds can be made with a variety of densities or by using a gradient
within a single construct
• Laminates: multiple scaffolds with different properties can be connected together,
such as collagen and synthetic polymer
• Directional Porosity: porosity gradients can be incorporated to allow cell infiltration
into only one side or end of the scaffold
• Additives: protein and polysaccharide coatings and/or microstructures can be
applied to the pores to improve biological properties. Growth factors, and other
biologics can also be incorporated with controlled-release properties.

Materials
Our PTM process works with most resorbable and non-resorbable polymers. We have produced scaffolds from:
• Polylactides
• Polylactide-co-glycolides
• Polycaprolactones
• Polycarbonates (e.g. TMC)
• Polyurethanes

Products
Our PTM process is used to create products for a wide variety of medical device applications. Currently, our product portfolio includes a dental barrier membrane, bone void filler and cement restrictor for use in total joint replacement procedures, all of which have regulatory approval.

Potential Applications
The PTM process is an ideal technology from which to produce medical devices for many other potential applications. We have late stage development programs underway on a structural spine implant, and a bi-phasic collagen and PTM device for cartilage repair.
Other potential applications have been evaluated in animal and in-vitro models including:

• Tissue Engineering Scaffold
• Graft Containment Device
• Spine Inter-body Fusion Cage
• Tissue Fixation Device
• Bone Graft Substitute
• Chemotherapeutic Drug Delivery Device
• Structural Synthetic Bone Graft
• Tissue Augmentation
• Nerve Conduit
• Growth Factor Delivery
• Small Diameter Vascular Graft